SMILES

Creating Graphical Objects

ACD/ChemSketch is the powerful all-purpose chemical drawing and graphics package from
ACD/Labs developed to help chemists quickly and easily draw molecular structures, reactions,
and schematic diagrams, calculate chemical properties, and design professional reports and
presentations.

ACD/ChemSketch includes:

• Structure mode for drawing chemical structures and calculating their properties.
• Draw mode or text and graphics processing.
• Additional modules that extend the ChemSketch possibilities (most of them should be
purchased separately).

3D MACROMOLECULE

Information 3D..:

Authors:
Luo, Y., Pfuetzner, R.A., Mosimann, S., Little, J.W., Strynadka, N.C.J.
Release Date: 2001-09-19 Classification: Hydrolase
Experiment: X-RAY DIFFRACTION with resolution of 2.00 Å
Compound: 1 Polymer [ Display Full Polymer Details | Display for All Results ]
Molecule: LEXA REPRESSOR
Polymer: 1 Type: polypeptide(L) Length: 137
Chains: A
EC#: 3.4.21.88
Fragment: C-Terminus, Residues 68-202
Mutation: S119A
Citation: Crystal structure of LexA: a conformational switch for regulation of self-cleavage.
(2001) Cell(Cambridge,Mass.) 106: 585-594

LexA repressor undergoes a self-cleavage reaction. In vivo, this reaction requires an activated form of RecA, but it occurs spontaneously in vitro at high pH. Accordingly, LexA must both allow self-cleavage and yet prevent this reaction in the absence of a stimulus. We have solved the crystal structures of several mutant forms of LexA. Strikingly, two distinct conformations are observed, one compatible with cleavage, and the other in which the cleavage site is approximately 20 A from the catalytic center. Our analysis provides insight into the structural and energetic features that modulate the interconversion between these two forms and hence the rate of the self-cleavage reaction. We suggest RecA activates the self-cleavage of LexA and related proteins through selective stabilization of the cleavable conformation.

Citation Authors:
Luo, Y., Pfuetzner, R.A., Mosimann, S., Paetzel, M., Frey, E.A., Cherney, M., Kim, B., Little, J.W., Strynadka, N.C.

[ Display Full Abstract | Display for All Results ]

Molecular Description..:
LEXA S119A C-TERMINAL TRYPTIC FRAGMENT

journey of life to kuantan

Bismillaahirrahmaanirrahiim n Assalaamualaikum..!! :)

It is 3.05pm now n I'm in my computer in science's class.We are asked to create a blog (for those who does not have yet lol).After struggling for an a half hour creating a blog (because i have to create gmail account first n there are some circumstances),at last,i have created my own blog!! ooo yeah!! hehe..^_^

i have been in UIA Kuantan for 2 weeks starting 6.7..what i can say about this university is..:

- beautiful
- hot
- peaceful
- many lecturers are foreigners as if we are studying at oversea but we can still eat malaysian's
food,that's the difference..hehe..

I came here one day earlier than registration day.It's to make sure that i don't get clumsiness while preparing the needed document.hehe.

I know,the journey to the kuantan is not only JOURNEY from kt (my hometown)-kuantan but also the jourmey into new life...;campus life which is synonym with busy,tiresome,blur n confuse (lecture is so fast.hehe)

but.....never mind,i will enjoy this journey till the end with full determination and courage.InshaAllah.Pray for me! ^_^..

Here,i'm taking degree in Biomedical Science which is 4 years course.I have to be here for four years..Gosh!! ='(.It sounds unhappy,right??hehe..no,honestly,i feel lucky to be one of the IIUM's student but what i feel disappointed most is there is no public transportation in order to go to Kuantan's town like bus so that we have to find our own transportation by renting senior's car and drive by ourselves.Other is by delivery service which is asking the 'person';who rents his or her car, send us to the place.That is why most of the students here bring his/her own car but for me as long as i can survive with this kind of life,no need for me to bring one too.hehe.